VOC breath biomarkers in lung cancer

Yannick Saalberg; Marcus Wolff

doi:10.1016/j.cca.2016.05.013

VOC breath biomarkers in lung cancer

Clin Chim Acta. 2016 Aug 1:459:5-9. doi: 10.1016/j.cca.2016.05.013. Epub 2016 May 21.

Authors

Yannick Saalberg¹, Marcus Wolff²

Affiliations

¹ Hamburg University of Applied Sciences, Heinrich Blasius Institute for Physical Technologies, Berliner Tor 21, 20099 Hamburg, Germany. Electronic address: yannick.saalberg@haw-hamburg.de.
² Hamburg University of Applied Sciences, Heinrich Blasius Institute for Physical Technologies, Berliner Tor 21, 20099 Hamburg, Germany.

PMID: 27221203
DOI: 10.1016/j.cca.2016.05.013

Abstract

This review provides an overview of volatile organic compounds (VOCs) which are considered lung cancer biomarkers for diagnostic breath analysis. It includes results of scientific publications from 1985 to 2015. The identified VOCs are listed and ranked according to their occurrence of nomination. The applied detection and sampling methods are specified but not evaluated. Possible reasons for the different results of the studies are stated. Among the most frequently emerging biomarkers are 2-butanone and 1-propanol as well as isoprene, ethylbenzene, styrene and hexanal. The outcome of this review may be helpful for the development of a lung cancer screening device.

Keywords: Biomarker; Breath analysis; Diagnostics; Lung cancer; Screening; VOC.

Publication types

Review

MeSH terms

Biomarkers, Tumor / analysis*
Breath Tests*
Humans
Lung Neoplasms / diagnosis*
Respiration
Volatile Organic Compounds / analysis*

Substances

Biomarkers, Tumor
Volatile Organic Compounds