Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

Adv Mater. 2016 Aug;28(30):6345-52. doi: 10.1002/adma.201600554. Epub 2016 May 11.

Abstract

Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.

Keywords: Alzheimer's disease; RNA; interference; magnetic resonance imaging; nanoparticles; neural stem cells.

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology
  • Alzheimer Disease / therapy*
  • Animals
  • Cell Differentiation* / drug effects
  • Cell Differentiation* / genetics
  • Cell Movement
  • Drug Liberation*
  • Mice
  • Nanoparticles / administration & dosage*
  • Neural Stem Cells / cytology*
  • RNA, Small Interfering / administration & dosage*
  • Tretinoin / administration & dosage*

Substances

  • RNA, Small Interfering
  • Tretinoin