Biol Chem Hoppe Seyler. 1989 Mar;370(3):191-203.

Isolation and structural characterization of twenty-one sialyloligosaccharides from galactosialidosis urine. An intact N,N'-diacetylchitobiose unit at the reducing end of a diantennary structure.

van Pelt J, Hård K, Kamerling JP, Vliegenthart JF, Reuser AJ, Galjaard H.

Source

Department of Bio-Organic Chemistry, Utrecht University.

Abstract

Galactosialidosis urine was fractionated by gel-permeation chromatography on Bio-Gel P-6. The obtained sialic acid-containing carbohydrate fractions were purified by reversed-phase chromatography and separated according to charge by medium-pressure anion-exchange chromatography on Mono Q. The Mono Q fractions, being mixtures of sialyloligosaccharides differing mainly in sialic acid-linkage type (alpha 2-3/alpha 2-6), were subfractionated by high-performance liquid chromatography on Lichrosorb-NH2. The purified compounds were analysed by 500-MHz 1H-NMR spectroscopy. Twenty-one fully and partially sialylated N-acetyllactosamine-type compounds include mono-, di-, tri- and tetra-antennary structures. All structures have the sequence Man beta 1-4Glc-NAc at the reducing terminus in common, except one diantennary structure bearing an intact N,N'-diacetylchitobiose unit at the reducing end, which is a new feature in human glycoproteinosis urine.

PMID:: 2713102; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine. [J Inherit Metab Dis. 1991]
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
Van Pelt J, Kamerling JP, Bakker HD, Vliegenthart JF. J Inherit Metab Dis. 1991; 14(5):730-40.
Storage of sialic acid-containing carbohydrates in the placenta of a human galactosialidosis fetus. Isolation and structural characterization of 16 sialyloligosaccharides. [Eur J Biochem. 1988]
Storage of sialic acid-containing carbohydrates in the placenta of a human galactosialidosis fetus. Isolation and structural characterization of 16 sialyloligosaccharides.
Van Pelt J, Van Kuik JA, Kamerling JP, Vliegenthart JF, Van Diggelen OP, Galjaard H. Eur J Biochem. 1988 Nov 1; 177(2):327-38.
Isolation and structural characterization of sialic acid-containing storage material from mucolipidosis I (sialidosis) fibroblasts. [Biochim Biophys Acta. 1988]
Isolation and structural characterization of sialic acid-containing storage material from mucolipidosis I (sialidosis) fibroblasts.
van Pelt J, Kamerling JP, Vliegenthart JF, Verheijen FW, Galjaard H. Biochim Biophys Acta. 1988 Apr 14; 965(1):36-45.
Structural analysis of the sialylated N- and O-linked carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells. Sialylation patterns and branch location of dimeric N-acetyllactosamine units. [Eur J Biochem. 1995]
Structural analysis of the sialylated N- and O-linked carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells. Sialylation patterns and branch location of dimeric N-acetyllactosamine units.
Hokke CH, Bergwerff AA, Van Dedem GW, Kamerling JP, Vliegenthart JF. Eur J Biochem. 1995 Mar 15; 228(3):981-1008.
Isolation and structure determination of the intact sialylated N-linked carbohydrate chains of recombinant human follitropin expressed in Chinese hamster ovary cells. [Eur J Biochem. 1990]
Isolation and structure determination of the intact sialylated N-linked carbohydrate chains of recombinant human follitropin expressed in Chinese hamster ovary cells.
Hård K, Mekking A, Damm JB, Kamerling JP, de Boer W, Wijnands RA, Vliegenthart JF. Eur J Biochem. 1990 Oct 5; 193(1):263-71.

See reviews... See all...

Cited by 1 PubMed Central article

A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable. [EMBO J. 1991]
A mutation in a mild form of galactosialidosis impairs dimerization of the protective protein and renders it unstable.
Zhou XY, Galjart NJ, Willemsen R, Gillemans N, Galjaard H, d'Azzo A. EMBO J. 1991 Dec; 10(13):4041-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Isolation and structural characterization of twenty-one sialyloligosaccharides f...
Isolation and structural characterization of twenty-one sialyloligosaccharides from galactosialidosis urine. An intact N,N'-diacetylchitobiose unit at the reducing end of a diantennary structure.
Biol Chem Hoppe Seyler. 1989 Mar ;370(3):191-203.

PubMed
Thoracotomy as adjuvant to chemotherapy in metastatic osteogenic sarcoma.
Thoracotomy as adjuvant to chemotherapy in metastatic osteogenic sarcoma.
J Pediatr Surg. 1977 Dec ;12(6):983-90.

PubMed
Trial of deltamethrin impregnated bed nets for the control of malaria transmitte...
Trial of deltamethrin impregnated bed nets for the control of malaria transmitted by Anopheles sinensis and Anopheles anthropophagus.
Am J Trop Med Hyg. 1989 Apr ;40(4):356-9.

PubMed
[Migraine and food].
[Migraine and food].
Recenti Prog Med. 1989 Feb ;80(2):53-5.

PubMed
Somatic symptoms in multiple personality disorder.
Somatic symptoms in multiple personality disorder.
Psychosomatics. 1989 Spring ;30(2):154-60.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: