Bone mineral disorder in chronic kidney disease: Klotho and FGF23; cardiovascular implications

Nefrologia. 2016 Jul-Aug;36(4):368-75. doi: 10.1016/j.nefro.2016.01.011. Epub 2016 Apr 23.
[Article in English, Spanish]

Abstract

Cardiovascular factors are one of the main causes of morbidity and mortality in patients with chronic kidney disease. Bone mineral metabolism disorders and inflammation are pathological conditions that involve increased cardiovascular risk in chronic kidney disease. The cardiovascular risk involvement of bone mineral metabolism classical biochemical parameters such as phosphorus, calcium, vitamin D and PTH is well known. The newest markers, FGF23 and klotho, could also be implicated in cardiovascular disease.

Keywords: Cardiovascular risk; Chronic kidney disease; Enfermedad renal crónica; FGF23; Klotho; Riesgo cardiovascular.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Bone and Bones / metabolism
  • Calcineurin / physiology
  • Cardiovascular Diseases / etiology
  • Chronic Kidney Disease-Mineral and Bone Disorder* / complications
  • Chronic Kidney Disease-Mineral and Bone Disorder* / metabolism
  • Fibroblast Growth Factor-23
  • Fibroblast Growth Factors / physiology
  • Glucuronidase / physiology
  • Humans
  • Klotho Proteins
  • Mice
  • Minerals / metabolism
  • Models, Biological
  • Parathyroid Hormone / physiology
  • Phosphorus / metabolism
  • Renal Insufficiency, Chronic / complications
  • Renal Insufficiency, Chronic / metabolism
  • Risk Factors
  • Vascular Calcification / etiology
  • Vascular Calcification / prevention & control
  • Vitamin D / metabolism

Substances

  • Biomarkers
  • FGF23 protein, human
  • Fgf23 protein, mouse
  • Minerals
  • Parathyroid Hormone
  • Vitamin D
  • Phosphorus
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Calcineurin
  • Glucuronidase
  • Klotho Proteins