The human resources play a decisive role in support of effective functioning of any health care system. The study was carried out to analyze characteristics offormation ofprofessional self-appraisal of graduates of comprehensive schools of the Republic of Kazakhstan choosing medical specialties. The study was organized in city of Pavlodar and the Pavlodarskaia oblast of the Republic of Kazakhstan. The sample included 447 schoolchildren of 9-10 classes, 25 workers of 3 urban and 1 rural schools, 12 lecturers of medical university. The questionnaire survey was applied. The statistical processing of data was implemented using SPSS v.20 software. It is established that medicine became a popular profession because it was chosen by 22% of schoolchildren. Out of them, only 37.4% belonged among personality type "human-human" corresponding to medical specialties. The childhood dream became main cause of choosing medicine among 55.6% of schoolchildren. The second place took perspective of employment and third place--insistent advice of parents (13.1% and 7.1% correspondingly). Only 31.3% of schoolchildren were aware of specificity of medical specialties and 52.5% had independent experience of initial medical care provision. The additional training is considered by 72.7% of schoolchildren as necessary for entering medical university. The workers of schools and medical university 65.5% and 66.7% limit themselves by once-only activities. The vocational guidance activities implemented in comprehensive schools of the Republic of Kazakhstan can be significantly ameliorated. The possibility of implementing personality type test is to be considered. The application of innovative methods of vocational guidance is to be considered too.