Synthesis of 1H-Indazoles from Imidates and Nitrosobenzenes via Synergistic Rhodium/Copper Catalysis

Org Lett. 2016 May 6;18(9):2102-5. doi: 10.1021/acs.orglett.6b00727. Epub 2016 Apr 15.

Abstract

Nitrosobenzenes have been used as a convenient aminating reagent for the efficient synthesis of 1H-indazoles via rhodium and copper catalyzed C-H activation and C-N/N-N coupling. The reaction occurred under redox-neutral conditions with high efficiency and functional group tolerance. Moreover, a rhodacyclic imidate complex has been identified as a key intermediate.

Publication types

  • Research Support, Non-U.S. Gov't