Diagnosis and Management of Hereditary Meningioma and Vestibular Schwannoma

Adam Shaw

doi:10.1007/978-3-319-29998-3_2

Diagnosis and Management of Hereditary Meningioma and Vestibular Schwannoma

Recent Results Cancer Res. 2016:205:17-27. doi: 10.1007/978-3-319-29998-3_2.

Author

Adam Shaw¹

Affiliation

¹ Department of Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. Adam.Shaw@gstt.nhs.uk.

PMID: 27075346
DOI: 10.1007/978-3-319-29998-3_2

Abstract

Bilateral vestibular schwannomata and meningiomata are the tumours most commonly associated with neurofibromatosis type II (NF2). These tumours may also be seen in patients with schwannomatosis and familial meningioma, but these phenotypes are usually easy to distinguish. The main diagnostic challenge when managing these tumours is distinguishing between sporadic disease which carries low risk of subsequent tumours or NF2 with its associated morbidities and reduced life expectancy. This chapter outlines some of the diagnostic and management considerations along with associated evidence.

Keywords: Meningioma; NF2; Neurofibromatosis type II; Schwannomatosis; Vestibular schwannoma.

MeSH terms

Diagnosis, Differential
Genetic Predisposition to Disease
Genetic Testing
Humans
Meningeal Neoplasms / diagnosis*
Meningeal Neoplasms / genetics
Meningeal Neoplasms / therapy*
Meningioma / diagnosis*
Meningioma / genetics
Meningioma / therapy*
Neoplastic Syndromes, Hereditary / diagnosis*
Neoplastic Syndromes, Hereditary / genetics
Neoplastic Syndromes, Hereditary / therapy*
Neuroma, Acoustic / diagnosis*
Neuroma, Acoustic / genetics
Neuroma, Acoustic / therapy*
Risk Assessment