The impact of serum uric acid on the natural history of glomerular filtration rate: a retrospective study in the general population

Ying Xu; Xiang Liu; Xiaohe Sun; Yibing Wang

doi:10.7717/peerj.1859

The impact of serum uric acid on the natural history of glomerular filtration rate: a retrospective study in the general population

PeerJ. 2016 Mar 29:4:e1859. doi: 10.7717/peerj.1859. eCollection 2016.

Authors

Ying Xu¹, Xiang Liu¹, Xiaohe Sun², Yibing Wang³

Affiliations

¹ Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong University , Jinan, Shandong , China.
² School of Medicine, Shandong University , Jinan, Shandong , China.
³ Department of Burns and Plastic Surgery, Shandong Provincial Hospital affiliated to Shandong University , Jinan, Shandong , China.

Abstract

Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the association of the SUA level with the GFR decline in a general population. Two thousand, seven hundred and eighty-nine subjects who visited the Health Checkup Clinic both at 2008 and 2013 were identified. A significant inverse correlation was observed between change in SUA from 2008-2013 (ΔSUA) and change in eGFR (ΔeGFR) during the same period. Multivariate regression analysis of ΔeGFR indicated that the increase in SUA over time were a negative predictor of the change in eGFR. Our result indicates that the decline of eGFR over years is larger in subjects with an increased SUA level, which helps to underline the importance of SUA level management in the context of kidney function preservation.

Keywords: Chronic kidney disease; Serum uric acid; eGFR.

Grants and funding

This work was supported by the National Natural Science Foundation of China (81571911, 81171818 to YW) and Grant BS2015YY018 from Shandong Provincial Natural Science Foundation to YX. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.