Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution

Br J Haematol. 2017 Mar;176(5):825-829. doi: 10.1111/bjh.13999. Epub 2016 Apr 7.

Authors

Carolyn S Grove^{1

2

3}, Niccolo Bolli^{1

4}, Nicla Manes¹, Ignacio Varela⁵, Mars Van't Veer⁶, Anthony Bench⁶, Hesham Eldaly⁶, David Wedge¹, Peter Van Loo¹, George S Vassiliou^{1

4

6}

Affiliations

¹ Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
² Department of Haematology, PathWest/Sir Charles Gairdner Hospital, Perth, Western Australia.
³ Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
⁴ Department of Haematology, University of Cambridge, Cambridge, UK.
⁵ Institute of Biomedicine and Biotechnology of Cantabria, Cantabria, Spain.
⁶ Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.

PMID: 27062498
DOI: 10.1111/bjh.13999

No abstract available

Keywords: NPM1; acute myeloid leukaemia; chronic myelomonocytic leukaemia; clonal evolution; sequencing.

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Leukemia, Myeloid, Acute / genetics
Middle Aged
Mutation
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Nucleophosmin

Substances

NPM1 protein, human
Nuclear Proteins
Nucleophosmin

Grants and funding