Lipid Rafts Assemble Dynein Ensembles

Trends Biochem Sci. 2016 May;41(5):393-394. doi: 10.1016/j.tibs.2016.03.005. Epub 2016 Apr 6.

Abstract

New work by Rai et al. identifies a novel mechanism regulating phagosome transport in cells: the clustering of dynein motors into lipid microdomains, leading to enhanced unidirectional motility. Clustering may be especially important for dynein, a motor that works most efficiently in teams.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biological Transport / drug effects
  • Cell Line
  • Dyneins / chemistry*
  • Dyneins / metabolism
  • Glycosphingolipids / isolation & purification
  • Glycosphingolipids / pharmacology
  • Kinesins / chemistry
  • Kinesins / metabolism
  • Leishmania donovani / chemistry
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Macrophages / ultrastructure
  • Membrane Fusion / drug effects
  • Membrane Microdomains / chemistry*
  • Membrane Microdomains / drug effects
  • Membrane Microdomains / metabolism
  • Mice
  • Microtubules / drug effects
  • Microtubules / metabolism*
  • Microtubules / ultrastructure
  • Phagocytosis / drug effects
  • Phagosomes / drug effects
  • Phagosomes / metabolism*
  • Phagosomes / ultrastructure

Substances

  • Glycosphingolipids
  • lipophosphonoglycan
  • Dyneins
  • Kinesins