Abstract
New work by Rai et al. identifies a novel mechanism regulating phagosome transport in cells: the clustering of dynein motors into lipid microdomains, leading to enhanced unidirectional motility. Clustering may be especially important for dynein, a motor that works most efficiently in teams.
Copyright © 2016 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Biological Transport / drug effects
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Cell Line
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Dyneins / chemistry*
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Dyneins / metabolism
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Glycosphingolipids / isolation & purification
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Glycosphingolipids / pharmacology
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Kinesins / chemistry
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Kinesins / metabolism
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Leishmania donovani / chemistry
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Macrophages / drug effects
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Macrophages / metabolism*
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Macrophages / ultrastructure
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Membrane Fusion / drug effects
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Membrane Microdomains / chemistry*
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Membrane Microdomains / drug effects
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Membrane Microdomains / metabolism
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Mice
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Microtubules / drug effects
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Microtubules / metabolism*
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Microtubules / ultrastructure
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Phagocytosis / drug effects
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Phagosomes / drug effects
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Phagosomes / metabolism*
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Phagosomes / ultrastructure
Substances
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Glycosphingolipids
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lipophosphonoglycan
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Dyneins
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Kinesins