Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus

Yuanmei Ma; Yu Zhang; Xueya Liang; Michael Oglesbee; Steven Krakowka; Andrew Niehaus; Guiping Wang; Aiqing Jia; Houhui Song; Jianrong Li

doi:10.1016/j.vetmic.2016.02.004

Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus

Vet Microbiol. 2016 Apr 15:186:90-6. doi: 10.1016/j.vetmic.2016.02.004. Epub 2016 Feb 9.

Authors

Yuanmei Ma¹, Yu Zhang², Xueya Liang², Michael Oglesbee², Steven Krakowka², Andrew Niehaus³, Guiping Wang⁴, Aiqing Jia⁴, Houhui Song⁵, Jianrong Li⁶

Affiliations

¹ Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: ma.194@osu.edu.
² Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
³ Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
⁴ Guangdong Haid Institute of Animal Husbandry & Veterinary, PanYu, Guangdong 511400, PR China.
⁵ College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Lin-An, Zhejiang 311300, PR China.
⁶ Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: li.926@osu.edu.

Abstract

Porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PdCV) cause indistinguishable clinical signs and pathological changes in swine. Here we investigated the antigenic relationship between PEDV and PdCV. We provide the first evidence that conserved epitope(s) on the respective viral nucleocapsid proteins cross-react with each other although virus neutralization cross-reactivity was not observed. As a practical matter, prevention of these two very similar diseases of swine will require the development of separate virus-specific vaccine products.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Viral / blood
Antibodies, Viral / immunology
Cell Line
Coronavirus / immunology*
Coronavirus Infections / immunology
Coronavirus Infections / veterinary*
Coronavirus Infections / virology
Cross Reactions / immunology
Intestines / immunology
Intestines / virology
Nucleocapsid Proteins / genetics
Nucleocapsid Proteins / immunology
Porcine epidemic diarrhea virus / immunology*
Specific Pathogen-Free Organisms
Swine
Swine Diseases / immunology*
Swine Diseases / virology*
Vero Cells

Substances

Antibodies, Viral
Nucleocapsid Proteins