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Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.
Department of Clinical Psychiatry, University of Milan, Italy.
Twenty-eight elderly inpatients suffering from major depressive episodes (diagnosed according to DSM III) received randomly, on a double-blind basis, amitriptyline (75 mg/die) or fluoxetine (20 mg/die) for five weeks. There were four drop-outs in the amitriptyline group and two drop-outs in the fluoxetine group. Both groups showed a significant amelioration at the end point for Hamilton Rating Scale of Depression scores compared to the baseline value. Anticholinergic side-effects were significantly more severe in the amitriptyline group. Weight gain was detected only in patients receiving amitriptyline.
PMID: 2699465 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance.
Brynne N, Svanström C, Aberg-Wistedt A, Hallén B, Bertilsson L.
Br J Clin Pharmacol. 1999 Oct; 48(4):553-63.
[Br J Clin Pharmacol. 1999]
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Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis.
Trindade E, Menon D, Topfer LA, Coloma C.
CMAJ. 1998 Nov 17; 159(10):1245-52.
[CMAJ. 1998]
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Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.
Song F, Freemantle N, Sheldon TA, House A, Watson P, Long A, Mason J.
BMJ. 1993 Mar 13; 306(6879):683-7.
[BMJ. 1993]
Patient Drug Information
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Amitriptyline (Limbitrol® (as a combination product containing amitriptyline and chlordiazepoxide), Limbitrol® DS (as a combination product containing amitriptyline and chlordiazepoxide))
Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are n...
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Fluoxetine (Prozac® , Prozac® Weekly, Sarafem® , ...)
Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...
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Bupropion (Wellbutrin, Wellbutrin, Wellbutrin XL, ...)
How do the newer antidepressants compare in treating depression?