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The functioning of the par-regions of the small multi-copied colicinogenic plasmids ColE1 and ColA has been analysed under the different conditions of plasmid-containing cells cultivation. The efficient cointegrate resolution of the multimeric forms of the plasmid ColE1 has been demonstrated in Escherichia coli K12 cells under the different conditions of cell cultivation. It took place at 30 degrees-42 degrees C on the minimal as well as rich medium, at the different stages of cell cycle in the presence or absence of antibiotic, under aerobic as well as semi-anaerobic conditions.
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