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Bioessays. 1989 Dec;11(6):168-70.

Trichothiodystrophy and the relationship between DNA repair and cancer.


The identification of cellular deficiencies in the ability to repair damage in DNA in individuals with several cancer-prone genetic disorders, has led to the idea that defective DNA repair results in cancer. In patients with trichothiodystrophy, however, a recently discovered defect in the repair of ultraviolet damage in DNA is not associated with cancer-proneness. Thus our previous ideas about the connections between DNA repair capacity and cancer susceptibility need to be reevaluated.

[PubMed - indexed for MEDLINE]
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