Intraoperative use of fibrin glue dyed with methylene blue in surgery for branchial cleft anomalies

Laryngoscope. 2016 Sep;126(9):2147-50. doi: 10.1002/lary.25833. Epub 2016 Mar 1.

Abstract

Objectives/hypothesis: We present a new method of optimizing the results of surgery for branchial cleft anomalies based on the intraoperative injection of fibrin glue combined with methylene blue dye.

Study design: Retrospective single-center cohort study.

Methods: The method was applied in 17 patients suffering from branchial anomalies. Six (35.29%) had a preauricular lesion; three (17.65%) had lesions derived from the first arch/pouch/groove (type I), four (23.53%) had lesions derived from the first (type II), one (5.88%) had lesions derived from the second, one (5.88%) had lesions derived from the third, and two (11.76%) had lesions derived from the fourth. The median and mean age at surgery were 10 and 10.6 years, respectively. All patients were followed by periodic clinical and ultrasonographic examination.

Results: The combination of fibrin glue with methylene blue facilitated the correct assessment of the extension of the lesions and their intraoperative manipulation. After a mean follow-up of 47.8 months, all patients were free of disease.

Conclusions: Intraoperative injection of branchial fistulae and cysts by a mixture of fibrin glue and methylene blue is an effective, easy, and safe tool to track lesions and achieve radical resection. The technique requires a definitive validation on a large cohort with adequate stratification of patients.

Level of evidence: 4 Laryngoscope, 126:2147-2150, 2016.

Keywords: Branchial cyst; branchial fistula; fibrin glue; methylene blue.

MeSH terms

  • Adolescent
  • Adult
  • Branchial Region / abnormalities*
  • Branchial Region / surgery
  • Child
  • Child, Preschool
  • Cohort Studies
  • Coloring Agents* / administration & dosage
  • Craniofacial Abnormalities / surgery*
  • Female
  • Fibrin Tissue Adhesive* / administration & dosage
  • Humans
  • Intraoperative Care / methods*
  • Male
  • Methylene Blue* / administration & dosage
  • Pharyngeal Diseases / surgery*
  • Retrospective Studies
  • Young Adult

Substances

  • Coloring Agents
  • Fibrin Tissue Adhesive
  • Methylene Blue

Supplementary concepts

  • Branchial Cleft Anomalies