Modular Approach to 9-Monosubstituted Fluorene Derivatives Using Mo(V) Reagents

Org Lett. 2016 Mar 4;18(5):1182-5. doi: 10.1021/acs.orglett.6b00315. Epub 2016 Feb 25.

Abstract

Oxidative coupling using molybdenum(V) reagents provides fast access to highly functionalized 9-monosubstituted fluorenes. This synthetic approach is highly modular, is high yielding, and tolerates a variety of labile moieties, e.g. amides or iodo groups. The established protocol leads to promising precursors for pharmacologically important analogues of melatonin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Combinatorial Chemistry Techniques
  • Fluorenes / chemical synthesis*
  • Fluorenes / chemistry
  • Fluorenes / pharmacology
  • Indicators and Reagents
  • Melatonin / analogs & derivatives
  • Melatonin / chemical synthesis
  • Melatonin / chemistry
  • Molecular Structure
  • Molybdenum / chemistry*
  • Oxidative Coupling

Substances

  • Fluorenes
  • Indicators and Reagents
  • Molybdenum
  • Melatonin