A number of chronic viral infections require special attention during pregnancy in the prenatal, perinatal and postnatal periods. In many rural areas of South Dakota, these conditions are present, but readily-accessible subspecialty consultation is not. Fortunately, most aspects of management of these conditions in pregnancy are easily within the scope of practice of primary care physicians. This paper presents a review of the management of pregnancies complicated by HBV, HCV, HIV, HPV and HSV, offering a quick-reference guide for physicians who may infrequently encounter these patients as a part of their practices.