Systemic Metal Ion Levels in Patients With Modular-Neck Stems: A Prospective Cohort Study

J Arthroplasty. 2016 Aug;31(8):1750-5. doi: 10.1016/j.arth.2016.01.030. Epub 2016 Jan 29.

Abstract

Background: Recent registry data reveal that modular-neck hip prostheses are associated with increased revision rates compared to fixed-neck stems. Poor implant survival has been associated to corrosion at the neck-stem junction, inducing metal ion release and subsequently adverse local tissue reactions. Data on metal ion release on the neck-stem junction of such stems are scarce. The purpose of this study was to evaluate corrosion at this interface by determining metal ion release.

Methods: Serum and whole blood metal ion levels of 40 patients after 1 year of implantation of a modular-neck stem (titanium stem and cobalt-chromium neck) were compared with 10 patients with a monobloc version of the stem (all titanium) and 10 patients having no implant at all.

Results: Seven of 40 patients (18%) with a modular-neck stem had cobalt or chromium concentrations >2 μg/L. These patients underwent magnetic resonance imaging using metal artifact reduction sequences, which revealed a pseudotumor in 1 patient.

Conclusion: Corrosion at the neck-stem junction of modular-neck stems is a reported phenomenon, which is in part reflected by elevated systemic ion levels. The use of such implants should be restricted to a minimum, and screening algorithms of patients with such implants must be developed.

Keywords: adverse local tissue reaction; arthroplasty; corrosion; hip; metal ion release; modular neck.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip
  • Chromium / blood*
  • Cobalt / blood*
  • Corrosion
  • Female
  • Hip Prosthesis / adverse effects*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Molybdenum / blood
  • Prospective Studies
  • Prosthesis Design
  • Prosthesis Failure
  • Registries
  • Titanium / blood

Substances

  • Chromium
  • Cobalt
  • Molybdenum
  • Titanium