Mitochondrial Damage Induces Senescence with a Twisted Arm

Pablo J Fernandez-Marcos; Manuel Serrano

doi:10.1016/j.cmet.2016.01.012

Mitochondrial Damage Induces Senescence with a Twisted Arm

Cell Metab. 2016 Feb 9;23(2):229-30. doi: 10.1016/j.cmet.2016.01.012.

Authors

Pablo J Fernandez-Marcos¹, Manuel Serrano²

Affiliations

¹ Bioactive Products and Metabolic Syndrome Group, Madrid Institute of Advanced Studies (IMDEA) Food, Madrid E28049, Spain. Electronic address: pablojose.fernandez@imdea.org.
² Tumor Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. Electronic address: mserrano@cnio.es.

PMID: 26863485
DOI: 10.1016/j.cmet.2016.01.012

Abstract

Cellular senescence is a damage response characterized by a stable cell-cycle arrest and an intense secretion of cytokines. In this issue of Cell Metabolism, Wiley et al. (2016) report that, in the case of mitochondrial damage, senescence occurs with an atypical secretory phenotype, in both adipose tissue and skin.

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MeSH terms

Arm*
Cell Cycle Checkpoints
Cellular Senescence
DNA Damage*
Humans
Phenotype