[Neuropsychological study in patients with Parkinson's disease: the effects of deep brain stimulation]

Rev Neurol. 2016 Feb 16;62(4):152-6.
[Article in Spanish]

Abstract

Introduction: Parkinson's disease (PD) is a disorder whose clinical manifestations are observed in the motor and neuropsychological domain and have an impact on the patient's quality of life. Several scientific studies evidence the effectiveness of deep brain stimulation as treatment for the motor symptoms, but further research is required on the neuropsychological symptoms.

Aim: To analyse the existence of significant differences in neuropsychological processes, such as attention, memory, language, visuoperception and the executive functions in patients with PD prior to and following deep brain stimulation.

Patients and methods: Our sample consisted of 20 patients of both sexes, aged 50-70 years, with PD, who were treated by healthcare service providers in Medellin. These subjects were administered the Continuous Performance Test and the Trail Making Test in order to assess attention, the Rey Complex Figure and Ardila memory tests to evaluate memory, the Boston and verbal fluency tests to assess language, the Rey Complex Figure Copy test for visuoperception, and the Wisconsin Card Sorting Test to appraise the executive functions.

Results: There are significant differences between the scores before and after deep brain stimulation in patients with PD on attention and memory.

Conclusions: Knowledge of these findings is relevant for the neuropsychological therapy of patients with PD.

Title: Estudio neuropsicologico en pacientes parkinsonianos: efectos de la estimulacion cerebral profunda.

Introduccion. La enfermedad de Parkinson (EP) es un trastorno cuyas manifestaciones clinicas se observan en el ambito motor y neuropsicologico e influyen en la calidad de vida del paciente. Diversos estudios cientificos muestran la eficacia de la estimulacion cerebral profunda como tratamiento sobre los sintomas motores, pero faltan estudios sobre los sintomas neuropsicologicos. Objetivo. Analizar la existencia de diferencias significativas en procesos neuropsicologicos, como la atencion, la memoria, el lenguaje, la visuopercepcion y la funcion ejecutiva en los pacientes con EP antes y despues de la estimulacion cerebral profunda. Pacientes y metodos. La muestra estuvo formada por 20 pacientes parkinsonianos de 50-70 años de ambos sexos, pertenecientes a entidades prestadoras de servicios de salud de Medellin, a los que se les administraron el Continuous Performance Test y el Trail Making Test para valorar la atencion, la figura compleja de Rey y la prueba de memoria de Ardila para evaluar la memoria, el test de Boston y fluidez verbal para valorar el lenguaje, la figura compleja de Rey copia para la visuopercepcion, y el test de clasificacion de cartas de Wisconsin para valorar la funcion ejecutiva. Resultados. Existen diferencias significativas entre las puntuaciones antes y despues de la estimulacion cerebral profunda en los pacientes con EP en la atencion y la memoria. Conclusiones. El conocimiento de estos hallazgos es relevante para la terapia neuropsicologica de los pacientes con EP.

MeSH terms

  • Aged
  • Attention
  • Deep Brain Stimulation* / psychology
  • Executive Function
  • Female
  • Humans
  • Language Disorders / etiology
  • Language Disorders / therapy
  • Male
  • Memory Disorders / etiology
  • Memory Disorders / therapy
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease / psychology*
  • Parkinson Disease / therapy
  • Speech Disorders / etiology
  • Speech Disorders / therapy
  • Treatment Outcome
  • Visual Perception