Abstract
This review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in Alzheimer disease. In particular tau, CD4 and TNF alpha were included in the review and the colocalizations of these factors were highlighted. It is important to realize the Alzheimer disease may result from the interactions of these factors. Some of these factors may coexist at the same region and at the same time e.g. mutated tau and amyloid in plaques. A summary scheme of etiology leading to the disease was included.
Keywords:
Amyloid; CD4; Microglia; Mutated tau; TNF alpha.
Copyright © 2016 Elsevier GmbH. All rights reserved.
MeSH terms
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Alzheimer Disease / diagnosis
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Alzheimer Disease / genetics*
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Alzheimer Disease / immunology
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Alzheimer Disease / pathology
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Amyloidogenic Proteins / genetics*
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Amyloidogenic Proteins / immunology
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Animals
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Brain / immunology
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Brain / pathology
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CD4 Antigens / genetics
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CD4 Antigens / immunology
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Cell Death
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Gene Expression
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Humans
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Inflammation
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Microglia / immunology
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Microglia / pathology
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Mutation*
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Plaque, Amyloid / diagnosis
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Plaque, Amyloid / genetics*
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Plaque, Amyloid / immunology
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Plaque, Amyloid / pathology
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / immunology
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tau Proteins / genetics*
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tau Proteins / immunology
Substances
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Amyloidogenic Proteins
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CD4 Antigens
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Tumor Necrosis Factor-alpha
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tau Proteins