A binding relationship with thrombin

Blood. 2016 Feb 4;127(5):525-6. doi: 10.1182/blood-2015-12-683466.

Abstract

In this issue of Blood, Estevez et al propose a model of platelet activation induced by low levels of thrombin and requiring 2 different platelet receptors that demonstrate a mutually dependent cooperativity.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood Platelets / cytology*
  • Humans
  • Platelet Activation*
  • Platelet Glycoprotein GPIb-IX Complex / metabolism*
  • Receptors, Proteinase-Activated / metabolism*
  • Signal Transduction*
  • Thrombin / metabolism*

Substances

  • Platelet Glycoprotein GPIb-IX Complex
  • Receptors, Proteinase-Activated
  • Thrombin