Amino acid sequence of human platelet factor 4. [Proc Natl Acad Sci U S A. 1977]

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1: Proc Natl Acad Sci U S A. 1977 Jun;74(6):2256-8. Links

Amino acid sequence of human platelet factor 4.

Deuel TF, Keim PS, Farmer M, Heinrikson RL.

Human platelet factor 4, a protein that binds heparin, has been purified to apparent homogeneity and the complete amino acid sequence of the protein has been determined. The 70-residue polypeptide chain contains no methionine, tryptophan, or phenylalanine, and contains only a single tyrosyl residue. The sequence analysis demonstrates a highly negatively charged amino-terminal region. The carboxyl-terminal region of the polypeptide is unusual in that it contains a repetitive clustering of positively charged and hydrophobic pairs of amino acids; preliminary evidence suggests that this domain may play a role in the binding of heparin.

PMID: 267922 [PubMed - indexed for MEDLINE]

PMCID: PMC432148

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Amino acid sequence of human platelet factor 4.

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