[First trimester screening of late-onset preeclampsia in a low risk and low volume obstetrical setting: external validation of a predictive model]

An Sist Sanit Navar. 2015 Sep-Dec;38(3):387-96. doi: 10.23938/ASSN.0279.
[Article in Spanish]

Abstract

Background: The external validation of predictive model of late preeclampsia in a low volume and low risk obstetrical setting.

Methods: A cohort was created of 174 singleton pregnancies of 11+0-13+6 gestational weeks at Clinica Universidad Navarra from September 2011 to March 2013, which was considered as a validation cohort of a previously described model for late PE (Hospital Clinic, Barcelona).

Results: A total of 7 (4%) women developed late PE. In the validation cohort the area under the curve of the model was 0.69 (95% CI 0.45-0.93). Detection rates for a 5, 10 and 15% of false positive rates were 21.9, 31.4% and 38.6% respec-tively. When comparing the areas under the curve of the validation cohort with the construction cohort, no statistical differences were found (p=0.68).

Conclusion: The combination of maternal history, pregnancy associated plasma protein-A and mean arterial pressure is moderately useful to predict preeclampsia in a low risk and low volume obstetrical setting. The predictive model of the Clinic Hospital of Barcelona is a valid tool in predicting late preeclampsia in this setting.

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Humans
  • Pre-Eclampsia / diagnostic imaging*
  • Pregnancy
  • Pregnancy Trimester, First