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Sex determining genes.
The development of a male or female phenotype is dependent upon the expression of sets of sex specific differentiation genes early in embryonic life. Selecting the appropriate set of genes requires a primary signal that is unique to males or females, and a set of sex determining genes that respond to the primary signal leading to activation of the correct differentiation pathway. A general model for sex determination is emerging from a study of developmental genes in a number of species. This article describes a number of sex determining genes and genetic pathways in detail, and discusses how apparently dissimilar pathways may have derived from each other during evolution.
PMID: 2678463 [PubMed - indexed for MEDLINE]
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