Dopamine D4 receptor antagonist inhibits melanogenesis through transcriptional downregulation of MITF via ERK signalling

Joon Min Jung; Su Yeon Kim; Woo Jin Lee; Jae Sung Hwang; Sung Eun Chang

doi:10.1111/exd.12943

Dopamine D4 receptor antagonist inhibits melanogenesis through transcriptional downregulation of MITF via ERK signalling

Exp Dermatol. 2016 Apr;25(4):325-8. doi: 10.1111/exd.12943. Epub 2016 Feb 26.

Authors

Joon Min Jung¹, Su Yeon Kim², Woo Jin Lee¹, Jae Sung Hwang³, Sung Eun Chang¹

Affiliations

¹ Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
² Asan Institute for Life Science, Seoul, Korea.
³ Department of Genetic Engineering, College of Life Sciences, Kyung Hee University, Yongin, Korea.

PMID: 26782007
DOI: 10.1111/exd.12943

No abstract available

Keywords: 667 trihydrochloride; L-750; dopamine D4 receptor antagonist; extracellular signal-regulated kinase; melanogenesis; microphthalmia-associated transcription factor.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Survival
Dopamine / chemistry
Dose-Response Relationship, Drug
Down-Regulation
Extracellular Signal-Regulated MAP Kinases / metabolism*
Humans
Melanins / metabolism
Melanocytes / cytology*
Melanocytes / drug effects
Microphthalmia-Associated Transcription Factor / metabolism*
Pyridines / chemistry
Pyrroles / chemistry
RNA, Messenger / metabolism
Receptors, Dopamine D4 / antagonists & inhibitors*
Signal Transduction

Substances

DRD4 protein, human
L 750667
MITF protein, human
Melanins
Microphthalmia-Associated Transcription Factor
Pyridines
Pyrroles
RNA, Messenger
Receptors, Dopamine D4
Extracellular Signal-Regulated MAP Kinases
Dopamine