Tailored Synthesis of Octopus-type Janus Nanoparticles for Synergistic Actively-Targeted and Chemo-Photothermal Therapy

Lingyu Zhang; Yinyin Chen; Zilu Li; Lu Li; Philippe Saint-Cricq; Chunxia Li; Jun Lin; Chungang Wang; Zhongmin Su; Jeffrey I Zink

doi:10.1002/anie.201510409

Tailored Synthesis of Octopus-type Janus Nanoparticles for Synergistic Actively-Targeted and Chemo-Photothermal Therapy

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2118-21. doi: 10.1002/anie.201510409. Epub 2016 Jan 6.

Authors

Lingyu Zhang¹, Yinyin Chen², Zilu Li³, Lu Li⁴, Philippe Saint-Cricq³, Chunxia Li⁵, Jun Lin², Chungang Wang⁶, Zhongmin Su¹, Jeffrey I Zink³

Affiliations

¹ Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China.
² State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China.
³ Department of Chemistry and Biochemistry, University of California, Los Angeles, 609 Charles E. Yong Dr. E, Los Angeles, CA, 90095, USA.
⁴ Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China. lil106@nenu.edu.cn.
⁵ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China. cxli@ciac.ac.cn.
⁶ Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin, 130024, P. R. China. wangcg925@nenu.edu.cn.

PMID: 26732130
DOI: 10.1002/anie.201510409

Abstract

A facile, reproducible, and scalable method was explored to construct uniform Au@poly(acrylic acid) (PAA) Janus nanoparticles (JNPs). The as-prepared JNPs were used as templates to preferentially grow a mesoporous silica (mSiO2 ) shell and Au branches separately modified with methoxy-poly(ethylene glycol)-thiol (PEG) to improve their stability, and lactobionic acid (LA) for tumor-specific targeting. The obtained octopus-type PEG-Au-PAA/mSiO2 -LA Janus NPs (PEG-OJNP-LA) possess pH and NIR dual-responsive release properties. Moreover, DOX-loaded PEG-OJNP-LA, upon 808 nm NIR light irradiation, exhibit obviously higher toxicity at the cellular and animal levels compared with chemotherapy or photothermal therapy alone, indicating the PEG-OJNP-LA could be utilized as a multifunctional nanoplatform for in vitro and in vivo actively-targeted and chemo-photothermal cancer therapy.

Keywords: active targeting; chemo-photothermal therapy; dual-stimuli responsive release; octopus-type Janus nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemistry
Acrylic Resins / pharmacology
Animals
Cell Death / drug effects
Cell Line, Tumor
Cell Survival / drug effects
Disaccharides / chemistry
Disaccharides / pharmacology
HeLa Cells
Hep G2 Cells
Humans
Infrared Rays
Lasers
Mice
Mice, Inbred Strains
Nanoparticles / chemistry*
Neoplasms, Experimental / drug therapy*
Neoplasms, Experimental / pathology
Organogold Compounds / chemical synthesis
Organogold Compounds / chemistry
Organogold Compounds / pharmacology*
Phototherapy
Polyethylene Glycols / chemistry
Polyethylene Glycols / pharmacology
Silicon Dioxide / chemistry
Silicon Dioxide / pharmacology
Structure-Activity Relationship
Temperature*

Substances

Acrylic Resins
Disaccharides
Organogold Compounds
Polyethylene Glycols
carbopol 940
lactobionic acid
Silicon Dioxide