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J Virol. 2015 Dec 30;90(6):3268-73. doi: 10.1128/JVI.02481-15.

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets.

Author information

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Faculty of Life Sciences, University of Vienna, Vienna, Austria.
  • 2Department of Biochemistry and Biomedical Sciences, Institute for Infectious Diseases Research, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.
  • 3Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • 4Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • 5Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • 6Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • 7Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA randy.albrecht@mssm.edu florian.krammer@mssm.edu.
  • 8Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health & Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA randy.albrecht@mssm.edu florian.krammer@mssm.edu.

Abstract

We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.

Copyright © 2016, American Society for Microbiology. All Rights Reserved.

PMID:
26719251
[PubMed - in process]
PMCID:
PMC4810634
[Available on 2016-08-26]
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