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J Neurol. 1989 May;236(4):214-7.

An immunohistochemical study of beta-protein in Alzheimer-type dementia brains.

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  • 1Department of Psychopharmacology, Psychiatric Research Institute of Tokyo, Japan.


An immunohistochemical study with a polyclonal anti-beta-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of beta-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.

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