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1: J Clin Psychiatry. 1989 Aug;50(8):290-4.Links

A comparative trial of fluoxetine versus trazodone in outpatients with major depression.

Perry PJ, Garvey MJ, Kelly MW, Cook BL, Dunner FJ, Winokur G.

Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.

The effectiveness of fluoxetine as an antidepressant was contrasted with trazodone in a 6-week double-blind trial in 40 patients. The total score on the Hamilton Rating Scale for Depression and the global improvement score on the Clinical Global Impressions scale favored trazodone at the end of 3 weeks of treatment. However, that difference was no longer apparent during the remainder of the study. The authors hypothesize that fluoxetine 20 mg/day may be an ineffective dosage of the drug or that fluoxetine has a slower onset of antidepressant action than does trazodone.

PMID: 2668259 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Fluoxetine (Prozac® , Prozac® Weekly, Sarafem® , ...)

    Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...

  • Bupropion (Wellbutrin, Wellbutrin, Wellbutrin XL, ...)

    How do the newer antidepressants compare in treating depression?

  • Trazodone

    Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balan...

  • Source: AHFS Consumer Medication Information