APMIS. 1989 Jul;97(7):575-84.

Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity.

Holmdahl R, Andersson ME, Goldschmidt TJ, Jansson L, Karlsson M, Malmström V, Mo J.

Source

Department of Medical and Physiological Chemistry, Uppsala University, Sweden.

Abstract

The type II collagen (CII) induced arthritis animal model (CIA) provides opportunities to study the nature of autoimmune reactions leading to arthritis and may be used as a model for rheumatoid arthritis (RA). Thus, in similarity with RA, the CIA model, when induced with autologous CII, shows a chronic and progressive disease course. The susceptibility to both RA and CIA are correlated to the expression of certain MHC class II allotype genes. In both diseases are autoantibodies to CII and rheumatoid factors produced. Immunohistopathology of affected joints show in both diseases a dominance of activated macrophages/fibroblasts with a significant infiltration of activated T cells and an infiltration of granulocytes. We do here suggest that both RA and CIA are dependent on a synergy between delayed type hypersensitivity and immune complex mediated inflammatory mechanisms and that CIA provides opportunities for studies of immunospecific reactions leading to arthritis.

PMID:: 2665798; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Collagen

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Review Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvement of both DTH and immune complex mediated mechanisms. [Clin Exp Rheumatol. 1989]
Review Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvement of both DTH and immune complex mediated mechanisms.
Holmdahl R, Mo J, Nordling C, Larsson P, Jansson L, Goldschmidt T, Andersson M, Klareskog L. Clin Exp Rheumatol. 1989 Sep-Oct; 7 Suppl 3:S51-5.
Review Immunopathogenesis of collagen arthritis. [Springer Semin Immunopathol. 2...]
Review Immunopathogenesis of collagen arthritis.
Brand DD, Kang AH, Rosloniec EF. Springer Semin Immunopathol. 2003 Aug; 25(1):3-18.
Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model. [J Immunol. 2003]
Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model.
Bäcklund J, Nandakumar KS, Bockermann R, Mori L, Holmdahl R. J Immunol. 2003 Oct 1; 171(7):3493-9.
Collagen-induced arthritis as a model for rheumatoid arthritis. [Methods Mol Med. 2004]
Collagen-induced arthritis as a model for rheumatoid arthritis.
Williams RO. Methods Mol Med. 2004; 98:207-16.
Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA). [Clin Exp Immunol. 1997]
Characteristics of synovial fluid effusion in collagen-induced arthritis (CIA) in the DA rat; a comparison of histology and antibody reactivities in an experimental chronic arthritis model and rheumatoid arthritis (RA).
Erlandsson Harris H, Liljeström M, Klareskog L. Clin Exp Immunol. 1997 Mar; 107(3):480-4.

See reviews... See all...

Cited by 13 PubMed Central articles

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. [Arthritis Res Ther. 2008]
Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study.
Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C, Sittinger M. Arthritis Res Ther. 2008; 10(1):R9. Epub 2008 Jan 18.
Review TNFalpha blockade in human diseases: mechanisms and future directions. [Clin Immunol. 2008]
Review TNFalpha blockade in human diseases: mechanisms and future directions.
Wong M, Ziring D, Korin Y, Desai S, Kim S, Lin J, Gjertson D, Braun J, Reed E, Singh RR. Clin Immunol. 2008 Feb; 126(2):121-36. Epub 2007 Oct 3.
Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint. [Clin Exp Immunol. 2006]
Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint.
Marinova-Mutafchieva L, Gabay C, Funa K, Williams RO. Clin Exp Immunol. 2006 Nov; 146(2):287-93.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Collagen induced arthritis as an experimental model for rheumatoid arthritis. Im...
Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity.
APMIS. 1989 Jul ;97(7):575-84.

PubMed
Impact of atmospheric dispersion and transport of viral aerosols on the epidemio...
Impact of atmospheric dispersion and transport of viral aerosols on the epidemiology of influenza.
Rev Infect Dis. 1989 May-Jun ;11(3):494-7.

PubMed
The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation.
The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation.
Nucleic Acids Res. 1989 Jun 26 ;17(12):4883-4.

PubMed
Role of nucleotide hydrolysis in the dynamics of actin filaments and microtubule...
Role of nucleotide hydrolysis in the dynamics of actin filaments and microtubules.
Int Rev Cytol. 1989 ;115:139-70.

PubMed
Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with...
Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54.
Am J Clin Pathol. 1977 May ;67(5):427-35.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: