Human SCNT Gets a Boost from Histone Demethylation

Alessia Deglincerti; Ali H Brivanlou

doi:10.1016/j.stem.2015.11.014

Human SCNT Gets a Boost from Histone Demethylation

Cell Stem Cell. 2015 Dec 3;17(6):641-642. doi: 10.1016/j.stem.2015.11.014.

Authors

Alessia Deglincerti¹, Ali H Brivanlou²

Affiliations

¹ Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY 10065, USA.
² Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, New York, NY 10065, USA. Electronic address: brvnlou@rockefeller.edu.

PMID: 26637938
DOI: 10.1016/j.stem.2015.11.014

Abstract

Human somatic cell nuclear transfer (SCNT) holds great potential in regenerative medicine; however, its applicability has been limited by great variability in reprogramming efficiencies. A new study in this issue of Cell Stem Cell reports a simple way to expand human SCNT to hard-to-reprogram oocytes (Chung et al., 2015).

Publication types

Comment

MeSH terms

Cellular Reprogramming
Histones*
Humans
Nuclear Transfer Techniques*
Oocytes

Substances

Histones