Advances in endovascular therapy to treat primary hepatocellular carcinoma

Drug Discov Ther. 2015 Oct;9(5):342-51. doi: 10.5582/ddt.2015.01057.

Abstract

Transcatheter arterial chemoembolization (TACE) is a minimally invasive procedure to restrict a tumor's blood supply, and TACE has an established role in cancer therapy. An embolic material in the form of microspheres (such as drug-eluting beads) and transarterial radioembolization is effective at treating hepatocellular carcinoma (HCC). Endovascular therapy offers promise for the treatment of tumor thrombi in the portal vein. Many researchers are anticipating an era of TACE with microspheres. This review aims to provide an overview of advances in endovascular therapy to treat primary HCC.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Carcinoma, Hepatocellular / mortality
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / therapy*
  • Chemoembolization, Therapeutic* / adverse effects
  • Chemoembolization, Therapeutic* / methods
  • Chemoembolization, Therapeutic* / trends
  • Diffusion of Innovation
  • Drug Carriers
  • Endovascular Procedures / adverse effects
  • Endovascular Procedures / methods*
  • Endovascular Procedures / mortality
  • Endovascular Procedures / trends
  • Humans
  • Liver Neoplasms / mortality
  • Liver Neoplasms / pathology
  • Liver Neoplasms / therapy*
  • Microspheres
  • Radiopharmaceuticals / administration & dosage*
  • Radiopharmaceuticals / adverse effects
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Radiopharmaceuticals