Replacing and safeguarding pancreatic β cells for diabetes

Sci Transl Med. 2015 Dec 2;7(316):316ps23. doi: 10.1126/scitranslmed.aaa9359.

Abstract

Pluripotent stem cells are a scalable source of pancreatic cells for transplantation into patients with diabetes. Here, we describe how the field is gaining momentum toward a β cell replacement therapy.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Cell Transplantation
  • Diabetes Mellitus / immunology
  • Diabetes Mellitus / therapy*
  • Humans
  • Immune System
  • Insulin-Secreting Cells / cytology*
  • Islets of Langerhans Transplantation
  • Mice
  • Pluripotent Stem Cells / cytology*

Substances

  • Blood Glucose