Arch Intern Med. 1989 Jul;149(7):1514-20.

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.

Source

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9030.

Abstract

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.

PMID:: 2662932; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Medical

Supplemental Content

Related citations

Central obesity in rhesus monkeys: association with hyperinsulinemia, insulin resistance and hypertriglyceridemia? [Int J Obes Relat Metab Disord. 1993]
Central obesity in rhesus monkeys: association with hyperinsulinemia, insulin resistance and hypertriglyceridemia?
Bodkin NL, Hannah JS, Ortmeyer HK, Hansen BC. Int J Obes Relat Metab Disord. 1993 Jan; 17(1):53-61.
Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women. [J Clin Endocrinol Metab. 2008]
Abdominal and gynoid fat mass are associated with cardiovascular risk factors in men and women.
Wiklund P, Toss F, Weinehall L, Hallmans G, Franks PW, Nordström A, Nordström P. J Clin Endocrinol Metab. 2008 Nov; 93(11):4360-6. Epub 2008 Aug 26.
Review [Treatment of obesity: the need to target attention on high-risk patients characterized by abdominal obesity]. [Cad Saude Publica. 2003]
Review [Treatment of obesity: the need to target attention on high-risk patients characterized by abdominal obesity].
Scarsella C, Després JP. Cad Saude Publica. 2003; 19 Suppl 1:S7-19. Epub 2003 Jul 21.
Hyperinsulinemia and clustering of cardiovascular risk factors in middle-aged hypertensive Finnish men and women. [J Hypertens. 1997]
Hyperinsulinemia and clustering of cardiovascular risk factors in middle-aged hypertensive Finnish men and women.
Vanhala MJ, Kumpusalo EA, Pitkäjärvi TK, Notkola IL, Takala JK. J Hypertens. 1997 May; 15(5):475-81.
Review Childhood obesity, adipose tissue distribution, and the pediatric practitioner. [Pediatrics. 1998]
Review Childhood obesity, adipose tissue distribution, and the pediatric practitioner.
Slyper AH. Pediatrics. 1998 Jul; 102(1):e4.

See reviews... See all...

Cited by 32 PubMed Central articles

The metabolic syndrome in Africa: Current trends. [Indian J Endocrinol Metab. 2012]
The metabolic syndrome in Africa: Current trends.
Okafor CI. Indian J Endocrinol Metab. 2012 Jan; 16(1):56-66.
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome. [J Nutr Metab. 2012]
Hypoadiponectinemia: A Link between Visceral Obesity and Metabolic Syndrome.
Di Chiara T, Argano C, Corrao S, Scaglione R, Licata G. J Nutr Metab. 2012; 2012:175245. Epub 2011 Oct 16.
The influence of laparoscopic sleeve gastrectomy on metabolic syndrome parameters in obese patients in own material. [Obes Surg. 2012]
The influence of laparoscopic sleeve gastrectomy on metabolic syndrome parameters in obese patients in own material.
Hady HR, Dadan J, Luba M. Obes Surg. 2012 Jan; 22(1):13-22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemi...
The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension.
Arch Intern Med. 1989 Jul ;149(7):1514-20.

PubMed
Microbial mineralization of ring-substituted anilines through an ortho-cleavage ...
Microbial mineralization of ring-substituted anilines through an ortho-cleavage pathway.
Appl Environ Microbiol. 1985 Aug ;50(2):447-53.

PubMed
The effects of nutrition and trauma on whole-body protein metabolism in man.
The effects of nutrition and trauma on whole-body protein metabolism in man.
Clin Sci (Lond). 1983 Aug ;65(2):165-75.

PubMed
Psychostimulant-like effects of p-fluoroamphetamine in the rat.
Psychostimulant-like effects of p-fluoroamphetamine in the rat.
Eur J Pharmacol. 1995 Dec 12 ;287(2):105-13.

PubMed
Clinical predictors of computed tomographic abnormalities following pediatric tr...
Clinical predictors of computed tomographic abnormalities following pediatric traumatic brain injury.
Pediatr Emerg Care. 1995 Feb ;11(1):1-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: