Results of Deep Anterior Lamellar Keratoplasty for Advanced Keratoconus in Children Less Than 18 Years

Am J Ophthalmol. 2016 Feb:162:191-198.e2. doi: 10.1016/j.ajo.2015.11.020. Epub 2015 Nov 18.

Abstract

Purpose: To evaluate the outcomes of deep anterior lamellar keratoplasty (DALK) in children with advanced keratoconus.

Design: Retrospective noncomparative interventional case series.

Methods: A retrospective analysis was conducted of 20 eyes of 16 patients who underwent deep anterior lamellar keratoplasty at a tertiary eye care center for advanced keratoconus. The main preoperative parameters measured were decimal uncorrected visual acuity (UCVA), decimal best-corrected visual acuity (BCVA), and average keratometry. The average keratometry was taken as an average of the flat and steep keratometric readings. The follow-up ranged from 24 to 105 months. The main outcome measures were UCVA, BCVA, steep and flat simulated keratometry, refraction, graft clarity, and complications.

Results: At the final follow-up, 18 patients had clear grafts in the visual axis area. Mean decimal UCVA changed from 0.06 ± 0.08 to 0.24 ± 0.09. Mean decimal BCVA changed from 0.12 ± 0.19 to 0.45 ± 0.24. The average keratometry decreased from 64.15 diopter (D) to 45.7 D after surgery. The complications noted in the patients were graft rejection (1), shield ulcers (2), graft infection (2), and interface vascularization (4). They were managed accordingly and only 1 patient needed penetrating keratoplasty.

Conclusions: DALK is an effective therapeutic modality for the management of advanced keratoconus in children.

MeSH terms

  • Adolescent
  • Cell Count
  • Child
  • Corneal Pachymetry
  • Corneal Transplantation*
  • Endothelium, Corneal / cytology
  • Female
  • Graft Survival / physiology
  • Humans
  • Intraocular Pressure / physiology
  • Intraoperative Complications
  • Keratoconus / physiopathology
  • Keratoconus / surgery*
  • Male
  • Postoperative Complications
  • Refraction, Ocular / physiology
  • Retrospective Studies
  • Treatment Outcome
  • Visual Acuity / physiology