Differential expression of CD25 and HC2 antigens on subtypes of acute myeloid leukemias

Eur J Haematol. 1989 May;42(5):436-40. doi: 10.1111/j.1600-0609.1989.tb01467.x.

Abstract

The presence of CD25 and HC2 antigens in 66 different patients with acute myeloid leukemia (AML) was investigated. The expression of both antigens was observed in 32% of AML cells. Dual fluorescence staining experiments performed in 5 AML patient cells showed that CD25 and HC2 antigens were simultaneously expressed in a single cell. The expression of both antigens was mainly observed in the M4 and M5 subtypes of AML. Although immunopurified IL-2 was able to block the binding of anti-CD25 monoclonal antibody to the AML cells, the IL-2 receptor did not appear to be functional.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Differentiation / analysis*
  • Fluorescent Antibody Technique
  • Humans
  • Interleukin-2 / pharmacology
  • Leukemia, Myeloid, Acute / immunology*
  • Leukemia, Myelomonocytic, Acute / immunology*
  • Receptors, Interleukin-2 / analysis*
  • Recombinant Proteins / pharmacology

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation
  • Interleukin-2
  • Receptors, Interleukin-2
  • Recombinant Proteins
  • hairy cell leukemia antigen, HC2, human