Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease

Allison E Girasole; Alexandra B Nelson

doi:10.1016/j.neuron.2015.11.007

Bridging the Gap: Muscarinic M4 Receptors Promote Striatal Plasticity in Health and Disease

Neuron. 2015 Nov 18;88(4):621-3. doi: 10.1016/j.neuron.2015.11.007.

Authors

Allison E Girasole¹, Alexandra B Nelson²

Affiliations

¹ Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
² Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: alexandra.nelson@ucsf.edu.

PMID: 26590337
DOI: 10.1016/j.neuron.2015.11.007

Abstract

In this issue of Neuron, Shen et al. (2015) demonstrate that the M4 muscarinic receptor regulates striatal plasticity. The authors use an M4-positive allosteric modulator, which facilitates long-term depression in direct pathway neurons and reverses aberrant plasticity in levodopa-induced dyskinesia.

Publication types

Comment

MeSH terms

Animals
Dopamine Agents / toxicity*
Dyskinesia, Drug-Induced / metabolism*
Levodopa / toxicity*
Neostriatum / drug effects*
Neuronal Plasticity / drug effects*
Parkinsonian Disorders / drug therapy*
RGS Proteins / metabolism*
Receptor, Muscarinic M4 / metabolism*

Substances

Dopamine Agents
RGS Proteins
Receptor, Muscarinic M4
Levodopa