Endocrine disruptors in 2015: Epigenetic transgenerational inheritance

Nat Rev Endocrinol. 2016 Feb;12(2):68-70. doi: 10.1038/nrendo.2015.206. Epub 2015 Nov 20.

Abstract

Endocrine disruptors are critical environmental exposures that influence health and can promote epigenetic transgenerational inheritance of disease and abnormal physiology. Advances in 2015 included analyses of the effects of endocrine disruptors on human disease, further examples of endocrine disruptors promoting transgenerational behavioural effects, insights into effects of endocrine disruptors on epigenetic programming of primordial germ cells and the finding that endocrine disruptors can transgenerationally promote genetic mutations.

Publication types

  • Review

MeSH terms

  • Diethylhexyl Phthalate / pharmacology
  • Endocrine Disruptors / pharmacology*
  • Epigenesis, Genetic / drug effects*
  • Epigenesis, Genetic / genetics
  • Female
  • Gene Expression / drug effects*
  • Germ Cells / drug effects*
  • Germ Cells / metabolism
  • Humans
  • Hypospadias / chemically induced
  • Hypospadias / genetics
  • Male
  • Mutation / drug effects*
  • Mutation / genetics
  • Oxazoles / pharmacology
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced
  • Prenatal Exposure Delayed Effects / genetics
  • RNA, Untranslated / drug effects
  • Spermatozoa / drug effects*
  • Spermatozoa / metabolism

Substances

  • Endocrine Disruptors
  • Oxazoles
  • RNA, Untranslated
  • Diethylhexyl Phthalate
  • vinclozolin