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Trends Biochem Sci. 1989 Mar;14(3):101-5.

From analysis to synthesis: new ligand binding sites on the lactate dehydrogenase framework. Part I.


In Part I of this article, the naturally evolved protein framework of lactate dehydrogenase is investigated by genetically introduced modifications which reveal the structural basis of its catalytic and substrate-binding properties. In Part II (to be published in the April issue of TIBS), this analytical information is exploited in the design of two modified forms of the enzyme; one which is specific for a new substrate and one which lacks allosteric regulation.

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