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J Surg Oncol. 1989 Jun;41(2):93-7.

Primary choriocarcinoma of the lung: report of a case treated with intensive multimodality therapy and review of the literature.

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  • 1Pananicolaou Comprehensive Cancer Center, University of Miami School of Medicine, Jackson Memorial Hospital, Florida.


Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

[PubMed - indexed for MEDLINE]
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