Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer

Jidong Xiao; Yuanquan Zhou; Bo Liu

Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer

Int J Clin Exp Med. 2015 Aug 15;8(8):13644-8. eCollection 2015.

Authors

Jidong Xiao¹, Yuanquan Zhou¹, Bo Liu²

Affiliations

¹ Department of Diagnostic Ultrasound, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.
² Department of Orthopedics, Third Xiangya Hospital, Central South University Changsha 410013, Hunan Province, China.

PMID: 26550308
PMCID: PMC4612993

Abstract

Objective: The aim was to explore the correlation of NGX6 expression with clinicopathological features and prognosis in colon cancer.

Methods: Clinicopathological feature of 145 patients with colon cancer were analyzed.NGX6 expression was measured using immunohistochemistry methods. The correlation of NGX6 expression with clinicopathological features and prognosis were assessed.

Results: Among 145 cases of colon cancer, NGX6 positive expression were found in 76 (52.4%) cases and NGX6 negative expression were found in 69 (47.6%) cases. The expression of NGX6 was closely associated with size tumor, lymph node metastasis and TNM stage (P=0.002, 0.012, and 0.039, respectively). Kaplan-Meier analysis showed that NGX6 negative expression was associated with shorter disease-free survival (DFS) (P=0.029) and overall survival (OS) (P=0.015). Multivariate survival analysis demonstrated that NGX6 expression was the important independent prognostic factor for colon cancer (P=0.022).

Conclusion: NGX6 is involved in the invasion and metastasis activity of colon cancer. NGX6 could may be applied as a novel and promising prognostic marker for colon cancer.

Keywords: Colon cancer; metastasis; nasopharyngeal carcinoma associated gene 6 (NGX6); pathology; prognosis.