Access to the Surugatoxin Alkaloids: Chemo-, Regio-, and Stereoselective Oxindole Annulation

Meagan E Hinze; Jessica L Daughtry; Chad A Lewis

doi:10.1021/acs.joc.5b02053

Access to the Surugatoxin Alkaloids: Chemo-, Regio-, and Stereoselective Oxindole Annulation

J Org Chem. 2015 Nov 20;80(22):11258-65. doi: 10.1021/acs.joc.5b02053. Epub 2015 Nov 5.

Authors

Meagan E Hinze¹, Jessica L Daughtry¹, Chad A Lewis¹

Affiliation

¹ Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University , Ithaca, New York 14853, United States.

PMID: 26539653
DOI: 10.1021/acs.joc.5b02053

Abstract

We report the synthesis of an aglycone of the surugatoxin family. The synthesis of this surugatoxin core was accomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.

Publication types

Research Support, Non-U.S. Gov't