Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis

Boban M Erovic; Manish D Shah; Guillem Bruch; Meredith Johnston; John Kim; Brian O'Sullivan; Bayardo Perez-Ordonez; Ilan Weinreb; Eshetu G Atenafu; John R de Almeida; Patrick J Gullane; Dale Brown; Ralph W Gilbert; Jonathan C Irish; David P Goldstein

doi:10.1186/s40463-015-0097-z

Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis

J Otolaryngol Head Neck Surg. 2015 Oct 29:44:43. doi: 10.1186/s40463-015-0097-z.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. boban.erovic@meduniwien.ac.at.
² Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. Manish.Shah@utoronto.ca.
³ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. guillembruch@yahoo.co.uk.
⁴ Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. Meredith.johnston@petermac.org.
⁵ Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. john.kim@rmp.uhn.on.ca.
⁶ Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada. brian.osullivan@rmp.uhn.on.ca.
⁷ Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. Bayardo.perez-ordonez@uhn.ca.
⁸ Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. ilan.weinreb@uhn.ca.
⁹ Department of Biostatistics, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. eatenafu@uhnresearch.ca.
¹⁰ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. john.dealmeida@uhn.ca.
¹¹ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. patrick.gullane@uhn.ca.
¹² Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. dale.brown@uhn.ca.
¹³ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. ralph.gilbert@uhn.ca.
¹⁴ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. jonathan.irish@uhn.ca.
¹⁵ Department of Otolaryngology-Head and Neck Surgery, Wharton Head and Neck Program, University Health Network, Princess Margaret Cancer Centre, Toronto, ON, Canada. david.goldstein@uhn.ca.
¹⁶ Princess Margaret Hospital, Wharton Head and Neck Centre, 610 University Avenue, 3rd Floor, Toronto, ON, M5G 2 M9, Canada. david.goldstein@uhn.ca.

Abstract

Background: To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital.

Methods: Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period.

Results: Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid carcinoma (n = 70) and salivary duct carcinoma (n = 19) have been included. The 5- and 10-year overall and disease-free survivals were 80.62%/69.48% and 74.37%/62.42%, respectively. Multivariable analysis showed that age greater than 60 years, advanced pN classification, histopathological grade and the presence of lymphovascular invasion significantly worsened overall and disease-free survival. Univariable analysis revealed periparotid lymph node involvement was associated with decreased overall (p < 0.0001) and disease-free survival (p < 0.0001).

Conclusions: In addition to age, pN classification, histopathological grade, perineural invasion, and lymphovascular involvement, periparotid lymph node metastasis appears to be an important prognosticator in parotid gland malignancy.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Disease-Free Survival
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Middle Aged
Ontario / epidemiology
Parotid Gland / pathology*
Parotid Neoplasms / diagnosis*
Parotid Neoplasms / mortality
Parotid Neoplasms / secondary
Prognosis
Retrospective Studies
Survival Rate / trends
Time Factors
Young Adult