Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease

Ozlem Celebi; Andac Uzdogan; Kader Karli Oguz; Arzu Ceylan Has; Anil Dolgun; Gul Yalcin Cakmakli; Filiz Akbiyik; Bulent Elibol; Esen Saka

doi:10.1016/j.archger.2015.09.010

Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease

Arch Gerontol Geriatr. 2016 Jan-Feb:62:125-32. doi: 10.1016/j.archger.2015.09.010. Epub 2015 Oct 17.

Authors

Ozlem Celebi¹, Andac Uzdogan², Kader Karli Oguz³, Arzu Ceylan Has⁴, Anil Dolgun⁵, Gul Yalcin Cakmakli¹, Filiz Akbiyik², Bulent Elibol⁶, Esen Saka⁷

Affiliations

¹ Hacettepe University, Institute of Health Sciences, Department of Neurological Sciences and Psychiatry, Ankara, Turkey.
² Hacettepe University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
³ Hacettepe University Faculty of Medicine, Department of Radiology, Ankara, Turkey.
⁴ Bilkent University, National Magnetic Resonance Research Center, Ankara, Turkey.
⁵ Hacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey.
⁶ Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey.
⁷ Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey. Electronic address: esensaka@hacettepe.edu.tr.

PMID: 26515126
DOI: 10.1016/j.archger.2015.09.010

Abstract

Background: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology.

Methods: Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls.

Results: DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD.

Conclusions: The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.

Keywords: Alzheimer’s disease; Biomarker; Cognition; Posterior cingulate cortex; Resting functional magnetic resonance imaging; Retrosplenial cortex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alzheimer Disease / cerebrospinal fluid*
Alzheimer Disease / physiopathology*
Amyloid beta-Peptides / cerebrospinal fluid*
Biomarkers / cerebrospinal fluid
Brain / pathology
Cerebral Cortex / physiopathology
Cognition / physiology
Cognition Disorders / diagnosis
Cognition Disorders / physiopathology
Female
Gyrus Cinguli / physiopathology*
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net / physiopathology*
Peptide Fragments / cerebrospinal fluid*
Phosphorylation
alpha-Synuclein / cerebrospinal fluid*
tau Proteins / cerebrospinal fluid*

Substances

Amyloid beta-Peptides
Biomarkers
Peptide Fragments
alpha-Synuclein
amyloid beta-protein (1-42)
tau Proteins