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1: FEBS Lett. 1989 Apr 10;247(1):154-8.Click here to read Links

The complete islet amyloid polypeptide precursor is encoded by two exons.

Institute of Molecular Biology and Medical Biotechnology, Utrecht, The Netherlands.

Islet amyloid polypeptide (IAPP) is the 37-amino acid peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the human gene encoding IAPP [(1988) FEBS Lett. 239, 227-232]. We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene. Two exons, which are approx. 5 kb apart in the human genome, encode the 89-amino acid pre-pro-IAPP. At least one additional exon is present further upstream in the IAPP gene. A putative signal sequence at the amino-terminus of the precursor suggests that IAPP is a secreted protein.

PMID: 2651160 [PubMed - indexed for MEDLINE]