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Bone Marrow Transplant. 1989 Mar;4(2):207-8.

Fatal hepatitis B reactivation after autologous bone marrow transplantation.

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  • 1Department of Virology, Royal Free Hospital, London, UK.


We report a fatal case of hepatitis B reactivation following autologous bone marrow transplantation for acute lymphocytic leukaemia. The presence of antibodies to HBs and HBc at presentation indicated previous infection with hepatitis B; these antibodies disappeared during the course of treatment for leukaemia. HBsAg was first detected in serum 5 weeks post-transplant; liver function tests began to deteriorate 8 weeks later, when HBeAg was first detected. The hepatitis followed a fulminant course, and the patient died 10 days later, in the 15th week following transplant.

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