Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population

Int Arch Occup Environ Health. 2016 May;89(4):621-8. doi: 10.1007/s00420-015-1100-8. Epub 2015 Oct 27.

Abstract

Objective: To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population.

Methods: The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay.

Results: We found that the APE1 -656 TT genotype was associated with a increased risk of NIHL [adjusted odds ratio (OR) 1.46, 95% confidence interval (CI) 1.05-2.06]. This increased risk was more pronounced in the stratification analysis. Furthermore, we found that subjects with two risk genotypes (hOGG1 Cys/Cys, APE1 -656 TT) had a significantly increased risk of NIHL (adjusted OR 1.91, 95% CI 1.27-2.88).

Conclusion: Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.

Keywords: APE1; Noise-induced hearing loss susceptibility; Polymorphisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • China / epidemiology
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Hearing Loss, Noise-Induced / epidemiology
  • Hearing Loss, Noise-Induced / genetics*
  • Humans
  • Male
  • Middle Aged
  • Noise, Occupational / adverse effects
  • Occupational Diseases / epidemiology
  • Occupational Diseases / genetics*
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Risk Factors

Substances

  • APEX1 protein, human
  • DNA-(Apurinic or Apyrimidinic Site) Lyase