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Science. 1989 Apr 7;244(4900):41-7.

The purine path to chemotherapy.

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  • 1Wellcome Research Laboratories, Burroughs Wellcome Company, Research Triangle Park, NC 27709.

Abstract

Research on antimetabolites of nucleic acid purines led to drugs for the treatment of acute leukemia (6-mercaptopurine and thioguanine), gout and hyperuricemia (allopurinol), and herpesvirus infections (acyclovir), and for the prevention of organ transplant rejection (azathioprine).

PMID:
2649979
[PubMed - indexed for MEDLINE]
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