Duke University Medical Center, Durham, North Carolina.
Cryptococcosis emphasizes the importance of the host-parasite interaction. C. neoformans has developed factors to invade the host but generally requires host immune dysfunction to establish infection. Cryptococcal infection has increased as our immunocompromised pool of patients enlarges. Although many questions regarding management of cryptococcosis remain, it is a well-studied infection with excellent guidelines for diagnosis, treatment, and prognosis.